Jul 18, 2017
Rapid Determination of Tumour Stroma Ratio in Squamous Cell Carcinomas with Desorption Electrospray Ionization Mass Spectrometry (DESI-MS): A Proof-Of-Concept Demonstration
M. Woolman, A. Tata, D. Dara, J. Means, E. D’Arcangelo, C. J. Perez, Sh. S. Prova, E. Bluemke, H. Ginsberg, D. R. Ifa, L. Ailles, A. McGuigan, A. Zarrine-Afsar , Analyst , DOI: 10.1039/C7AN00830A
Squamous cell carcinomas constitute a major class of head & neck cancers, where tumour stroma ratio (TSR) carries prognostic information. Patients affected by stroma-rich tumours exhibit poor prognosis and a higher chance of relapse. As such, there is a need for a technology platform that allows rapid determination of tumour...
Jul 14, 2017
Expansion of BCR/ABL1+ cells requires PAK2 but not PAK1
L. Edlinger, A. Berger-Becvar, I. Menzl, G. Hoermann, G. Greiner, E. Grundschober, Z. Bago-Horvath, W. Al-Zoughbi, G. Hoefler, C. Brostjans, L. Gille, R. Moriggl, A. Spittler, V. Sexl, A. Hoelbl-Kovacic , British Journal of Haematology , DOI: 10.1111/bjh.14833
The p21-activated kinases (PAKs) are key nodes in oncogenic signalling pathways controlling growth, survival, and motility of cancer cells. Their activity is increased in many human cancers and is associated with poor prognosis. To date, PAK deregulation has mainly been studied in solid tumours, where PAK1 and PAK4 are the...
Jul 11, 2017
A PML/Slit Axis Controls Physiological Cell Migration and Cancer Invasion in the CNS
V. Amodeo, Deli A, J. Betts, S. Bartesaghi, Y. Zhang, A. Richard-Londt, M. Ellis, R. Roshani, M. Vouri, S. Galavotti, S. Oberndorfer, A. P. Leite, A. Mackay, A. Lampada, E. W. Stratford, N. Li, D. Dinsdale, D. Grimwade, C. Jones, P. Nicotera, D. Michod, S. Brandner, P. Salomoni, P. Salomoni , Cell Reports , DOI: 10.1016/j.celrep.2017.06.047
Cell migration through the brain parenchyma underpins neurogenesis and glioblastoma (GBM) development. Since GBM cells and neuroblasts use the same migratory routes, mechanisms underlying migration during neurogenesis and brain cancer pathogenesis may be similar. Here, we identify a common pathway controlling cell migration in normal and neoplastic cells in the CNS....
Jul 6, 2017
Expression of monoacylglycerol lipase as a marker of tumour invasion and progression in malignant melanoma
Y. Baba, T. Funakoshi, M. Mori, K. Emoto, Y. Masugi, S. Ekmekcioglu, M. Amagai, K. Tanese , Journal of the European Academy of Dermatology and Venerology , DOI: 10.1111/jdv.14455
Background: Accumulating evidence suggests that the lipid lytic enzyme monoacylglycerol lipase (MAGL) promotes tumour invasion and metastasis through up-regulation of pro-tumourigenic signalling lipids in several tumour cell lines. However, the expression status of MAGL in clinical melanoma tissues and its clinico-pathological significance remain unclear.Objective: To correlate the tumour expression status...
Jul 5, 2017
Personalized RNA mutanome vaccines mobilize poly-specific therapeutic immunity against cancer
U. Sahin, E. Derhovanessian, M. Miller, B.-P. Kloke, P. Simon, M. Löwer, V. Bukur, A. D. Tadmor, U. Luxemburger, B. Schrörs, T. Omokoko, M. Vormehr, C. Albrecht, A. Paruzynski, A. N. Kuhn, J. Buck, S. Heesch, K. H. Schreeb, F. Müller, I. Ortseifer, I. Vogler, E. Godehardt, S. Attig, R. Rae, A. Breitkreuz, C. Tolliver, M. Suchan, G. Martic, A. Hohberger, P. Sorn, J. Diekmann, J. Ciesla, O. Waksmann, A.-K. Brück, M. Witt, M. Zillgen, A. Rothermel, B. Kasemann, D. Langer, S. Bolte, M. Diken, S. Kreiter, R. Nemecek, C. Gebhardt, S. Grabbe, C. Höller, J. Utikal, C. Huber, C. Loquai, Ö. Türeci , nature , DOI: 10.1038/nature23003
T cells directed against mutant neo-epitopes drive cancer immunity. However, spontaneous immune recognition of mutations is inefficient. We recently introduced the concept of individualized mutanome vaccines and implemented an RNA-based poly-neo-epitope approach to mobilize immunity against a spectrum of cancer mutations1, 2. Here we report the first-in-human application of this...