Scientific Literature

Oct 28, 2017

Characterization of male breast cancer: results of the EORTC 10085/TBCRC/BIG/NABCG International Male Breast Cancer Program

F. Cardoso, J. M. S. Bartlett, L. Slaets, C. H. M. van Deurzen, E. van Leeuwen-Stok, P. Porter, B. Linderholm, I. Hedenfalk, C Schröder, J. Martens, J. Bayani, C. van Asperen M. Murray, C. Hudis, L. Middleton, J. Vermeij, K. Punie, J. Fraser, M. Nowaczyk, I. T. Rubio, S. Aebi, C. Kelly, K. J. Ruddy, E. Winer, C Nilsson, L. Dal Lago, L. Korde, K. Benstead, O. Bogler, T. Goulioti, A. Peric, S. Litière, K. C. Aalders, C. Poncet, K. Tryfonidis, S. H. Giordano , Annals of Oncology , DOI: 10.1093/annonc/mdx651
Background: Male breast cancer (BC) is rare, managed by extrapolation from female BC. The International Male BC Program aims to better characterize and manage this disease. We report the results of part I, a retrospective joint analysis of cases diagnosed during a 20-year period.Methods: Patients with follow-up and tumor samples,...
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Oct 24, 2017

A CD3-bispecific molecule targeting P-cadherin demonstrates T cell-mediated regression of established solid tumors in mice

T. S. Fisher, A. T. Hooper, J. Lucas, T. H. Clark, A. K. Rohner, B. Peano, M. W. Elliott, K. Tsaparikos, H. Wang, J. Golas, M. Gavriil, N. Haddish-Berhane, L. Tchistiakova, H.-P. Gerber, A. R. Root, C. May , Cancer Immunology, Immunotherapy , DOI: 10.1007/s00262-017-2081-0
Strong evidence exists supporting the important role T cells play in the immune response against tumors. Still, the ability to initiate tumor-specific immune responses remains a challenge. Recent clinical trials suggest that bispecific antibody-mediated retargeted T cells are a promising therapeutic approach to eliminate hematopoietic tumors. However, this approach has...
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Oct 11, 2017

Human adipose-derived stem cells support the growth of limbal stem/progenitor cells

H. Mei, S. González, M. N. Nakatsu, E. R. Baclagon, F. V. Chen, S. X. Deng , PLoS One , DOI: 10.1371/journal.pone.0186238
The most efficient method to expand limbal stem cells (LSCs) in vitro for clinical transplantation is to culture single LSCs directly on growth-arrested mouse fibroblast 3T3 cells. To reduce possible xenobiotic contamination from 3T3s, primary human adipose-derived stem cells (ASCs) were examined as feeder cells to support the expansion of...
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Oct 7, 2017

Lack of myeloid Fatp1 increases atherosclerotic lesion size in Ldlr−/− mice

L. Zhao, A. J.Cozzo, A. R.Johnson, T. Christensen, A. J. Freemerman, J. E. Bear, J. D.Rotty, B. J. Bennett, L. Makowski , Atherosclerosis , DOI: 10.1016/j.atherosclerosis.2017.10.009
Background and aims: Altered metabolism is an important regulator of macrophage (MΦ) phenotype, which contributes to inflammatory diseases such as atherosclerosis. Broadly, pro-inflammatory, classically-activated MΦs (CAM) are glycolytic while alternatively-activated MΦs (AAM) oxidize fatty acids, although overlap exists. We previously demonstrated that MΦ fatty acid transport protein 1 (FATP1, Slc27a1)...
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Oct 2, 2017

Breast cancer risk factors in relation to estrogen receptor, progesterone receptor, insulin-like growth factor-1 receptor, and Ki67 expression in normal breast tissue

H. Oh, A. H. Eliassen, A. H. Beck, B. Rosner, S. J. Schnitt, L. C. Collins, J. L. Connolly, L. Montaser-Kouhsari, W. C. Willett, R. M. Tamimi , NPJ Breast Cancer , DOI: 10.1038/s41523-017-0041-7
Studies have suggested that hormone receptor and Ki67 expression in normal breast tissue are associated with subsequent breast cancer risk. We examined the associations of breast cancer risk factors with estrogen receptor (ER), progesterone receptor (PR), insulin-like growth factor-1 receptor (IGF-1R), and Ki67 expression in normal breast tissue. This analysis...
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