Feb 5, 2018
Comprehensive characterization of chorionic villi-derived mesenchymal stromal cells from human placenta
M. S. Ventura Ferreira, M. Bienert, K. Müller, B. Rath, T. Goecke, C. Opländer, T. Braunschweig, P. Mela, T. H. Brümmendorf, F. Beier, S. Neuss , Stem Cell Research & Therapy , DOI: 10.1186/s13287-017-0757-1
Background: Studies in which mesenchymal stromal cells (MSC) from the placenta are compared with multiple MSC types from other sources are rare. The chorionic plate of the human placenta is mainly composed of fetal blood vessels embedded in fetal stroma tissue, lined by trophoblastic cells and organized into chorionic villi...
Feb 1, 2018
Telmisartan Therapy Does Not Improve Lymph Node or Adipose Tissue Fibrosis More Than Continued Antiretroviral Therapy Alone
N. S. Utay D. W. Kitch, E. Yeh, C. J. Fichtenbaum, M. M. Lederman, J. D. Estes, C. Deleage, C. Magyar, S. D. Nelson, K. L. Klingman, B. Bastow, A. E. Luque, G. A. McComsey D. C. Douek J. S. Currier, J. E. Lake , The Journal of Infectious Diseases , DOI: 0.1093/infdis/jiy064
Background: Fibrosis in lymph nodes may limit CD4+ T-cell recovery, and lymph node and adipose tissue fibrosis may contribute to inflammation and comorbidities despite antiretroviral therapy (ART). We hypothesized that the angiotensin receptor blocker and peroxisome proliferator-activated receptor γ agonist telmisartan would decrease lymph node or adipose tissue fibrosis in...
Jan 22, 2018
Impact of glutathione peroxidase 4 on cell proliferation, angiogenesis and cytokine production in hepatocellular carcinoma
N.Rohr-Udilova, E. Bauer, G.Timelthaler, R. Eferl, K. Stolze, M. Pinter, M. Seif, H. Hayden, T. Reiberger, R. Schulte-Hermann, M. Peck-Radosavljevic, D. Stoiber, M. Trauner , Oncotarget , DOI: 10.18632/oncotarget.24300
Insufficient supplementation with the micronutrient selenium and persistent hepatic inflammation predispose to hepatocellular carcinoma (HCC). Inflammation-associated reactive oxygen species attack membrane lipids and form lipid hydroperoxides able to propagate oxidative hepatic damage. Selenium-containing enzyme glutathione peroxidase 4 (GPx4) antagonizes this damage by reducing lipid hydroperoxides to respective hydroxides. However, the...
Jan 3, 2018
Palbociclib synergizes with BRAF and MEK inhibitors in treatment naïve melanoma but not after the development of BRAF inhibitor resistance
C. A. Martin, C. Cullinane, L. Kirby, S. Abuhammad, E. J. Lelliott, K. Waldeck, R. J. Young, N. Brajanovski, D. P. Cameron, R. Walker, E. Sanij, G. Poortinga, R. D. Hannan, R. B. Pearson, R. J. Hicks, G. A. McArthur, K. E. Sheppard , International Journal of Cancer , DOI: 10.1002/ijc.31220
Increased CDK4 activity occurs in the majority of melanomas and CDK4/6 inhibitors in combination with BRAF and MEK inhibitors are currently in clinical trials for the treatment of melanoma. We hypothesize that the timing of the addition of CDK4/6 inhibitors to the current BRAF and MEK inhibitor regime will impact...
Dec 28, 2017
Intraepithelial CD8 (+) Lymphocytes as a Predictive Diagnostic Biomarker for the Remission of Oral Lichen Planus
A. Enomoto, E. Sato, T. Yasuda, T. Isomura, T. Nagao, D. Chikazu , Science Direct , DOI: 10.1016/j.humpath.2017.12.008
Oral lichen planus (OLP) is an autoimmune inflammatory disease of the oral mucosa whose etiology remains unknown. Moreover, the possibility of OLP being a premalignant change is under debate. Various types of immune cells infiltrate the OLP lesion and affect its clinicopathological features. However, the diversity of infiltrating immune cells...