Mar 23, 2012
Blocking ephrin-B2 with highly specific antibodies inhibits angiogenesis, lymphangiogenesis, and tumor growth
M. A. Abéngozar, S. de Frutos, S. Ferreiro, J. Soriano, M. Perez-Martinez, D. Olmeda, M. Marenchino, M. Cañamero, S. Ortega, D. Megias, A. Rodriguez, J. L. Martínez-Torrecuadrada , Blood , DOI: 10.1182/blood-2011-09-380006
Membrane-anchored ephrinB2 and its receptor EphB4 are involved in the formation of blood and lymphatic vessels in normal and pathological conditions. Eph/ephrin activation requires cell-cell interactions and leads to bidirectional signaling pathways in both ligand- and receptor-expressing cells. To investigate the functional consequences of blocking ephrinB2 activity, two highly specific...
Mar 13, 2012
Cohesin-SA1 deficiency drives aneuploidy and tumourigenesis in mice due to impaired replication of telomeres
S. Remeseiro, A. Cuadrado, M. Carretero, P. Martínez, W. C. Drosopoulos, M. Cañamero, C. L. Schildkraut, M. A. Blasco, A. Losada , The EMBO Journal , DOI: 10.1038/emboj.2012.11
Cohesin is a protein complex originally identified for its role in sister chromatid cohesion, although increasing evidence portrays it also as a major organizer of interphase chromatin. Vertebrate cohesin consists of Smc1, Smc3, Rad21/Scc1 and either stromal antigen 1 (SA1) or SA2. To explore the functional specificity of these two...
Feb 26, 2012
Depletion of the p43 mitochondrial T3 receptor in mice affects skeletal muscle development and activity
Pessemesse L, Schlernitzauer A, Sar C, Levin J, Grandemange S, Seyer P, Favier FB, Kaminski S, Cabello G, Wrutniak-Cabello C, Casas F , FASEB J , Volume 26, Issue 2, pp. 748-56
In vertebrates, skeletal muscle myofibers display different contractile and metabolic properties associated with different mitochondrial content and activity. We have previously identified a mitochondrial triiodothyronine receptor (p43) regulating mitochondrial transcription and mitochondrial biogenesis. When overexpressed in skeletal muscle, it increases mitochondrial DNA content, stimulates mitochondrial respiration, and induces a shift...
Feb 24, 2012
Late motor decline after accomplished remyelination: Impact for progressive multiple sclerosis
N. Manrique-Hoyos, MSc, T. Jürgens, MSc, M. Grønborg, PhD, M. Kreutzfeldt, MSc, M. Schedensack, T. Kuhlmann, MD, C. Schrick, W. Brück, MD, H. Urlaub, PhD, M. Simons, MD, D. Merkler, MD , Annals of neurology , DOI: 10.1002/ana.22681
Objective: To investigate the impact of single or repeated episodes of reversible demyelination on long-term locomotor performance and neuroaxonal integrity, and to analyze the myelin proteome after remyelination and during aging.Methods: Long-term locomotor performance of previously cuprizone-treated animals was monitored using the motor skill sequence (MOSS). Quantitative analysis of myelin...
Feb 18, 2012
Identification of novel pathways involved in the pathogenesis of human adamantinomatous craniopharyngioma
C. L. Andoniadou, C. Gaston-Massuet, R. Reddy, R. P. Schneider, M. A. Blasco, P. Le Tissier, T. S. Jacques, L. H. Pevny, M. T. Dattani, J.P. Martinez-Barbera , Acta Neuropathol , DOI: 10.1007/s00401-012-0957-9
Activating mutations in the gene encoding β-catenin have been identified in the paediatric form of human craniopharyngioma (adamantinomatous craniopharyngioma, ACP), a histologically benign but aggressive pituitary tumour accounting for up to 10% of paediatric intracranial tumours. Recently, we generated an ACP mouse model and revealed that, as in human ACP,...