Oct 17, 2011
MALDI Imaging Identifies Prognostic Seven-Protein Signature of Novel Tissue Markers in Intestinal-Type Gastric Cancer
B. Balluff, S. Rauser, S. Meding, M. Elsner, C. Schöne, A. Feuchtinger, Ch. Schuhmacher, A. Novotny, U. Jütting, G. Maccarrone, H. Sarioglu, M. Ueffing, H. Braselmann, H. Zitzelsberger, R. M. Schmid, H. Höfler, M. P. Ebert, A. Walch , The American Journal of Pathology , DOI: 10.1016/j.ajpath.2011.08.032
Proteomics-based approaches allow us to investigate the biology of cancer beyond genomic initiatives. We used histology-based matrix-assisted laser desorption/ionization (MALDI) imaging mass spectrometry to identify proteins that predict disease outcome in gastric cancer after surgical resection. A total of 181 intestinal-type primary resected gastric cancer tissues from two independent patient...
May 30, 2011
Global defects in collagen secretion in a Mia3/TANGO1 knockout mouse
Wilson DG, Phamluong K, Li L, Sun M, Cao TC, Liu PS, Modrusan Z, Sandoval WN, Rangell L, Carano RA, Peterson AS, Solloway MJ , J Cell Biol , Volume 193, Issue 5, pp 935-51
Melanoma inhibitory activity member 3 (MIA3/TANGO1/ARNT) is an evolutionarily conserved endoplasmic reticulum resident transmembrane protein. Recent in vitro studies have shown that it is required for the loading of collagen VII, but not collagen I, into COPII-coated transport vesicles. In this paper, we show that mice lacking Mia3 are defective...
May 13, 2011
Genes Associated With Prognosis After Surgery For Malignant Pleural Mesothelioma Promote Tumor Cell Survival In Vitro
G. J. Gordon, R. Bueno and D. J. Sugarbaker , BMC Cancer , DOI: 10.1186/1471-2407-11-169
Background: Mesothelioma is an aggressive neoplasm with few effective treatments, one being cytoreductive surgery. We previously described a test, based on differential expression levels of four genes, to predict clinical outcome in prospectively consented mesothelioma patients after surgery. In this study, we determined whether any of these four genes could...
Apr 14, 2011
The telomerase activator TA-65 elongates short telomeres and increases health span of adult/old mice without increasing cancer incidence
Here, we show that a small-molecule activator of telomerase (TA-65) purified from the root of Astragalus membranaceus is capable of increasing average telomere length and decreasing the percentage of critically short telomeres and of DNA damage in haploinsufficient mouse embryonic fibroblasts (MEFs) that harbor critically short telomeres and a single...
Mar 27, 2011
A reversible form of axon damage in experimental autoimmune encephalomyelitis and multiple sclerosis
I. Nikić, D. Merkler, C. Sorbara, M. Brinkoetter, M. Kreutzfeldt, F. M. Bareyre, W. Brück, D. Bishop, T. Misgeld, M. Kerschensteiner , Nature Medicine , DOI:10.1038/nm.2324
In multiple sclerosis, a common inflammatory disease of the central nervous system, immune-mediated axon damage is responsible for permanent neurological deficits. How axon damage is initiated is not known. Here we use in vivo imaging to identify a previously undescribed variant of axon damage in a mouse model of multiple...