Mar 26, 2010
T cell-dependence of Lassa fever pathogenesis
Flatz L, Rieger T, Merkler D, Bergthaler A, Regen T, Schedensack M, Bestmann L, Verschoor A, Kreutzfeldt M, Brück W, Hanisch UK, Günther S, Pinschewer DD , PLoS Pathog. , e1000836, Mar 26,2010
Lassa virus (LASV), the causative agent of Lassa fever (LF), is endemic in West Africa, accounting for substantial morbidity and mortality. In spite of ongoing research efforts, LF pathogenesis and mechanisms of LASV immune control remain poorly understood. While normal laboratory mice are resistant to LASV, we report that mice...
Mar 1, 2010
Safety and Efficacy of an Inhaled Epidermal Growth Factor Receptor Inhibitor (BIBW 2948 BS) in Chronic Obstructive Pulmonary Disease
P. G. Woodruff, M. Wolff, J. M. Hohlfeld, N. Krug, M. T. Dransfield, E. R. Sutherland, G. J. Criner, V. Kim, A. Prasse, M. C. Nivens, K. Tetzlaff, R. Heilker, J. V. Fahy , American journal of respiratory and critical care medicine , DOI: 10.1164/rccm.200909-1415OC
Rationale: Epidermal growth factor receptor (EGFR) activation is implicated in mucin hypersecretion in chronic obstructive pulmonary disease (COPD).Objectives: To investigate the safety and efficacy of an inhaled EGFR antagonist (BIBW 2948) in COPD.Methods: Multicenter, double-blind, placebo-controlled trial of 4 weeks of treatment with two doses of BIBW 2948 (15 and...
Jan 8, 2010
Drosophila Genome-wide Obesity Screen Reveals Hedgehog as a Determinant of Brown versus White Adipose Cell Fate
J. A. Pospisilik, D. Schramek, H. Schnidar, S. J. Cronin, N. T. Nehme, X. Zhang, C. Knauf, P. D. Cani, K. Aumayr, J. Todoric, M. Bayer, A. Haschemi, V. Puviindran, K. Tar, M. Orthofer, G. G. Neely, G. Dietzl, A. Manoukian, M. Funovics, G. Prager, O. Wagner O, D. Ferrandon, F. Aberger, C.-c. Hui, H. Esterbauer, J. M. Penninger , Cell , DOI: 10.1016/j.cell.2009.12.027
Over 1 billion people are estimated to be overweight, placing them at risk for diabetes, cardiovascular disease, and cancer. We performed a systems-level genetic dissection of adiposity regulation using genome-wide RNAi screening in adult Drosophila. As a follow-up, the resulting approx. 500 candidate obesity genes were functionally classified using muscle-,...
Dec 5, 2005
Hexagonal Packing of Drosophila Wing Epithelial Cells by the Planar Cell Polarity Pathway
A.-K. Classen, K. I. Anderson, E. Marois, S. Eaton , Developmental Cell , DOI: 10.1016/j.devcel.2005.10.016
The mechanisms that order cellular packing geometry are critical for the functioning of many tissues, but they are poorly understood. Here, we investigate this problem in the developing wing of Drosophila. The surface of the wing is decorated by hexagonally packed hairs that are uniformly oriented by the planar cell...
Jul 7, 2005
Genome-wide analysis of human kinases in clathrin- and caveolae/raft-mediated endocytosis
L. Pelkmans, E. Fava, H. Grabner, M. Hannus, B. Habermann, E. Krausz, M. Zerial , nature , DOI: 10.1038/nature03571
Endocytosis is a key cellular process, encompassing different entry routes and endocytic compartments. To what extent endocytosis is subjected to high-order regulation by the cellular signalling machinery remains unclear. Using high-throughput RNA interference and automated image analysis, we explored the function of human kinases in two principal types of endocytosis:...