Oct 14, 2010
Structural long-term changes at mushroom body input synapses
M. C. Kremer, F. Christiansen, F. Leiss, M. Paehler, S. Knapek, T. F. Andlauer, F. Förstner, P. Kloppenburg, S. J. Sigrist, G. Tavosanis , Current Biology , DOI: 10.1016/j.cub.2010.09.060
How does the sensory environment shape circuit organization in higher brain centers? Here we have addressed the dependence on activity of a defined circuit within the mushroom body of adult Drosophila. This is a brain region receiving olfactory information and involved in long-term associative memory formation. The main mushroom body...
Oct 1, 2010
Deciphering membrane-associated molecular processes in target tissue of autoimmune uveitis by label-free quantitative mass spectrometry
Hauck SM, Dietter J, Kramer RL, Hofmaier F, Zipplies JK, Amann B, Feuchtinger A, Deeg CA, Ueffing M , Molecular & Cellular Proteomics , 2010 9, pp. 2292-2305
Autoimmune uveitis is a blinding disease presenting with autoantibodies against eye-specific proteins as well as autoagressive T cells invading and attacking the immune-privileged target tissue retina. The molecular events enabling T cells to invade and attack the tissue have remained elusive. Changes in membrane protein expression patterns between diseased and...
Aug 19, 2010
Antibody-based proteomics: fast-tracking molecular diagnostics in oncology
D. J. Brennan, D. P. O'Connor, E. Rexhepaj, F. Ponten, W. M. Gallagher , Nature Reviews Cancer , DOI: 10.1038/nrc2902
The effective implementation of personalized cancer therapeutic regimens depends on the successful identification and translation of informative biomarkers to aid clinical decision making. Antibody-based proteomics occupies a pivotal space in the cancer biomarker discovery and validation pipeline, facilitating the high-throughput evaluation of candidate markers. Although the clinical utility of these...
Jun 15, 2010
PTPL1/PTPN13 regulates breast cancer cell aggressiveness through direct inactivation of Src kinase
Glondu-Lassis M, Dromard M, Lacroix-Triki M, Nirdé P, Puech C, Knani D, Chalbos D, Freiss G , Cancer Research , Volume 70, Issue 12, pp. 5116-26, May 25, 2010
The protein tyrosine phosphatase PTPL1/PTPN13, the activity of which is decreased through allelic loss, promoter methylation, or somatic mutations in some tumors, has been proposed as a tumor suppressor gene. Moreover, our recent clinical study identified PTPL1 expression level as an independent prognostic indicator of a favorable outcome for patients...
Jun 8, 2010
High-content phenotypic profiling of drug response signatures across distinct cancer cells
Caie PD, Walls RE, Ingleston-Orme A, Daya S, Houslay T, Eagle R, Roberts ME, Carragher NO , Molecular Cancer Therapeutics , doi: 10.1158/1535-7163.MCT-09-1148
The application of high-content imaging in conjunction with multivariate clustering techniques has recently shown value in the confirmation of cellular activity and further characterization of drug mode of action following pharmacologic perturbation. However, such practical examples of phenotypic profiling of drug response published to date have largely been restricted to...