Jul 7, 2005
Genome-wide analysis of human kinases in clathrin- and caveolae/raft-mediated endocytosis
L. Pelkmans, E. Fava, H. Grabner, M. Hannus, B. Habermann, E. Krausz, M. Zerial , nature , DOI: 10.1038/nature03571
Endocytosis is a key cellular process, encompassing different entry routes and endocytic compartments. To what extent endocytosis is subjected to high-order regulation by the cellular signalling machinery remains unclear. Using high-throughput RNA interference and automated image analysis, we explored the function of human kinases in two principal types of endocytosis:...